Abstract

Objectives: In the present study, the effect of selenium nanoparticles (SeNPs) and ferulic acid (FA) on acrylamide (AC) induced neurotoxicity in rats was investigated. Methods: Sixty adult male rats were divided equally into six groups and orally treated as follows: Group I (control): 1ml per day physiological saline; group II (SeNPs): 0.5 mg/kg body weight per day SeNPs for 21 days; group III (FA): 100 mg/kg body weight per day FA for 21 days; group IV (AC): 50 mg/kg body weight per day acrylamide for 21 days; group V (AC+SeNPs): AC was administrated as group IV then SeNPs was administrated like group II. Group VI (AC+ FA): AC was administrated as group IV then FA was given as group III. Results: AC significantly (P<0.05) decreased the level of Epinephrine (EPI), norepinephrine (NE) and Serotonin (SER) while, it significantly (P<0.05) increased the level of Acetylcholinestrase (AChE) in the brain tissue compared to control group. Treatment with SeNPs significantly (P<0.05) increased the level of EPI, NE, and SER in the brain tissue, while treatment with FA significantly (P<0.05) increased the level of NE and SER and induced non-significant changes in EPI level. The treatment with FA or SeNPs significantly decreased the level of AChE in the brain tissue compared to the AC group. Conclusion: It is concluded from the present study that both FA and SeNPs has a potent therapeutic effects against AC induced neurotoxicity in experimental rats.