Abstract

Objective: The evident data is insufficient in explaining association between the serum level of vitamin D and an occurrence of severe coronary artery disease. Vitamin D deficiency has been linked to an increased risk of cor onary artery disease (CAD) and cardiovascular (CV) death. We aimed to investigate whether serum 25 hydroxy vitamin D was associated with severity of cor onary artery involvement. Methods: 341 patients fulfilled the criteria of the Rose questionnaire and Minnesota codes on coronary arter y disease were consecutively included into this cross sectional survey. The number of involved coronary ve ssels were assessed by reviewing the coronary ang iography reports. 25-hydroxy vitamin D was measured by radioimmunoassay. Results: Lower 25-hydroxy v itamin D was found in those with more severe coronary disease (normal cor onary condition 26.78 ± 17.07, one-vessel 17.70 ± 14.31 ng/ml, two-vessel 17.49 ± 16.10 ng/ml, and three-vessel 16.04 ± 12.17 ng/dl, p =0.029). The prevalence rate of vitamin D defic iency in a normal coronary state, single vessel disease ,two-vessel disease, and three-vessel di sease were 31.2%,72.9%, 73.9%,78.7%respectively (p= 0.001). The level of vitamin was adversely associated only with serum triglyceride level (r = -0.156, p = 0.005), but not with other lipid profiles or FBS. Also, the serum level of 25-hydroxy vitamin D was directly correlated with patients’ age (r = 0.203, p < 0.001). Conclusions: Vitamin D deficiency can predispose to develop coronary artery involvement and pr ogress coronary atherosclerosis.